Author

J. C. S. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. T. Denham· 3 shared B. Brammer· 2 shared J. Bednarek· 2 shared M. A. Wambaugh· 2 shared C. L. Worne· 1 shared J. M. Daugherty· 1 shared K. Chung· 1 shared K. Y. Chung· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

S. T. Denham

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Author profile →

4 papers

Recent·Most cited

Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a point mutation in adenylate cyclase with drastic tradeoffs for pathogenicity

Z. Hilbert, K. Chung, J. Bednarek, M. Schwiesow, J. C. S. Brown, N. C. Elde

The paper identifies a point mutation in adenylate cyclase that improves fungal growth in macrophages but reduces disease severity in mice.

bioRxiv · Sep 27, 2022 · PreprintMicrobiology

A dissemination-prone morphotype enhances extrapulmonary organ entry by the fungus Cryptococcus neoformans

S. T. Denham, B. Brammer, K. Y. Chung, M. A. Wambaugh, J. Bednarek, L. Guo, J. C. S. Brown

This study shows that a small morphotype of Cryptococcus neoformans, called 'seed' cells, is critical for extrapulmonary organ entry and is induced by environmental factors like phosphate.

bioRxiv · Aug 27, 2020Microbiology

synergistic and antagonistic drug interactions in the treatment of systemic fungal infections

M. A. Wambaugh, S. T. Denham, B. Brammer, M. A. Stonhill, J. C. S. Brown

The paper identifies 40 synergistic and 19 antagonistic drug interactions with fluconazole using a high-throughput method, improving treatment for systemic fungal infections.

bioRxiv · Nov 15, 2019Microbiology

Regulated release of cryptococcal polysaccharide drives virulence and suppresses immune cell infiltration into the central nervous system

S. T. Denham, S. Verma, R. C. Reynolds, C. L. Worne, J. M. Daugherty, T. E. Lane, J. C. S. Brown

This study shows that regulated release of exo-GXM by Cryptococcus neoformans affects virulence and suppresses immune cell infiltration into the brain during infection.

bioRxiv · Sep 10, 2017Microbiology