CD95 receptor activation by ligand-induced trimerization is independent of its partial pre-ligand assembly
C. Liesche, J. Berndt, F. Fricke, S. Aschenbrenner, M. Heilemann, R. Eils, J. Beaudouin
This paper investigates how CD95 receptor activation occurs through ligand-induced trimerization, showing that receptor multimerization follows ligand binding while FADD recruitment is delayed, and that soluble CD95L is a poor inducer of apoptosis due to inefficient FADD recruitment.
bioRxiv · Apr 2, 2018 · PreprintCell Biology