R. Eils

Enhanced Airway Epithelial Response to SARS-CoV-2 Infection in Children is Critically Tuned by the Cross-Talk Between Immune and Epithelial Cells

This study identifies enhanced cytokine-mediated cross-talk between immune and epithelial cells in children as a mechanism for their improved antiviral response to SARS-CoV-2.

Transcriptionally defined morphological subtypes of pancreatic ductal adenocarcinoma

The paper identifies five transcriptional subtypes of PDAC cells with distinct morphological patterns and confirms their prognostic significance using bulk RNA-sequencing datasets.

Temporal control of the integrated stress response by a stochastic molecular switch

The paper identifies a stochastic molecular switch controlling the integrated stress response through cooperative activation of PKR, ultrasensitive eIF2 phosphorylation, and negative feedback via GADD34.

Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoids.

This study uses patient-derived PDAC organoids to integrate genomic, transcriptomic, and drug response data, identifying novel biomarkers and resistance mechanisms for personalized treatment.

Intratumoural heterogeneity and immune modulation in lung adenocarcinoma of female smokers and never smokers

The paper examines intratumoural heterogeneity and immune modulation in lung adenocarcinoma, focusing on female smokers and never smokers, identifying distinct cellular subpopulations and immune interactions.

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

This study examines DNA methylation heterogeneity in multiple myeloma, linking it to transcriptomic variability and poor patient outcomes through epigenetic and structural changes.

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

The paper uses single-cell RNA sequencing to analyze PDAC organoids and identifies conserved cell states and a differentiation hierarchy linked to tumor subtypes.

Automated screening by 3D light-sheet microscopy with high spatial and temporal resolution reveals mitotic phenotypes

The paper presents a workflow using 3D light-sheet microscopy and automated image processing to screen mitotic phenotypes in 3D cell cultures with high throughput.

Induced aneuploidy disrupts MCF10A acini formation and CCND1 expression

This study shows that induced aneuploidy disrupts MCF10A acini formation and upregulates CCND1 expression through altered promoter-enhancer interactions.

The landscape of viral associations in human cancers

The paper systematically investigates viral associations in human cancers using whole-genome and transcriptome data from 2,656 donors, revealing prevalence of known tumor-associated viruses and their genomic impacts.

Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics

This study uses human brain organoids and single-cell transcriptomics to model GBM invasion, identifying transcriptional changes and potential therapeutic targets.

Single-fluorescent protein reporters allow parallel quantification of NK cell-mediated granzyme and caspase activities in single target cells

The paper develops single-fluorescent protein reporters to measure granzyme and caspase activities in individual target cells, revealing a 6-minute delay between granzyme B and caspase-3 activation.

CD95 receptor activation by ligand-induced trimerization is independent of its partial pre-ligand assembly

This paper investigates how CD95 receptor activation occurs through ligand-induced trimerization, showing that receptor multimerization follows ligand binding while FADD recruitment is delayed, and that soluble CD95L is a poor inducer of apoptosis due to inefficient FADD recruitment.

Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations

The paper compares drug responses in ovarian cancer organoids and monolayer cultures, finding differences in drug efficacy and genomic associations.