Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan
J. Grzegorzewski, J. Brandhorst, M. König
The paper develops a PBPK model to study how CYP2D6 polymorphisms affect dextromethorphan metabolism and metabolic phenotyping using urinary cumulative metabolic ratios.
bioRxiv · Aug 23, 2022Pharmacology & Toxicology