Author

J. Grzegorzewski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 2 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1 Research Focus:clustering· 1 Approach:experimental assay· 1

Frequent Co-Authors

M. König· 4 shared A. Köller· 2 shared H.-M. Tautenhahn· 2 shared E. Kindler· 1 shared F. Bartsch· 1 shared J. Brandhorst· 1 shared J. Kuettner· 1 shared J. Rosendorf· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersPharmacology & Toxicology

M. König

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Author profile →

4 papers

Recent·Most cited

Cross-Species Variability in Lobular Geometry and Cytochrome P450 Hepatic Zonation: Insights into CYP1A2, CYP2E1, CYP2D6 and CYP3A4

M. Albadry, J. Kuettner, J. Grzegorzewski, O. Dirsch, E. Kindler, R. Klopfleisch, V. Liska, V. Moulisova, S. Nickel, R. Palek, J. Rosendorf, S. Saalfeld, U. Settmacher, H.-M. Tautenhahn, M. König, U. Dahmen

This study compares lobular geometry and CYP450 zonation across four species using whole slide imaging, identifying species differences and determining the minimum number of lobules needed for statistical analysis.

bioRxiv · Dec 28, 2023Pathology

Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan

J. Grzegorzewski, J. Brandhorst, M. König

The paper develops a PBPK model to study how CYP2D6 polymorphisms affect dextromethorphan metabolism and metabolic phenotyping using urinary cumulative metabolic ratios.

bioRxiv · Aug 23, 2022Pharmacology & Toxicology

Pharmacokinetics of caffeine: A systematic analysis of reported data for application in metabolic phenotyping and liver function testing

J. Grzegorzewski, F. Bartsch, A. Köller, M. König

This paper systematically analyzes caffeine pharmacokinetics data from 148 studies to improve metabolic phenotyping and liver function testing by addressing inter-individual variability factors.

bioRxiv · Jul 12, 2021Pharmacology & Toxicology

Prediction of survival after partial hepatectomy using a physiologically based pharmacokinetic model of indocyanine green liver function tests

A. Köller, J. Grzegorzewski, H.-M. Tautenhahn, M. König

This paper develops a physiologically based pharmacokinetic model of ICG to predict postoperative survival after liver resection, validated with pharmacokinetic data.

bioRxiv · Jun 15, 2021Physiology