M. König

Simulation of zonation-function relationships in the liver using coupled multiscale models: Application to drug-induced liver injury

The paper presents a multiscale liver model coupling PDE and ODE-based approaches to simulate drug-induced liver injury and zonation patterns.

Cross-Species Variability in Lobular Geometry and Cytochrome P450 Hepatic Zonation: Insights into CYP1A2, CYP2E1, CYP2D6 and CYP3A4

This study compares lobular geometry and CYP450 zonation across four species using whole slide imaging, identifying species differences and determining the minimum number of lobules needed for statistical analysis.

Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan

The paper develops a PBPK model to study how CYP2D6 polymorphisms affect dextromethorphan metabolism and metabolic phenotyping using urinary cumulative metabolic ratios.

Pharmacokinetics of caffeine: A systematic analysis of reported data for application in metabolic phenotyping and liver function testing

This paper systematically analyzes caffeine pharmacokinetics data from 148 studies to improve metabolic phenotyping and liver function testing by addressing inter-individual variability factors.

Prediction of survival after partial hepatectomy using a physiologically based pharmacokinetic model of indocyanine green liver function tests

This paper develops a physiologically based pharmacokinetic model of ICG to predict postoperative survival after liver resection, validated with pharmacokinetic data.

Polymerization of misfolded protein lowers CX3CR1 expression in human PBMCs

This study shows that polymerized misfolded Z-AAT protein reduces CX3CR1 expression on human PBMCs, suggesting a role for extracellular misfolded proteins in immune regulation.

Harmonizing semantic annotations for computational models in biology

The paper analyzes semantic annotation practices in the COMBINE community and proposes recommendations for a consensus protocol to improve interoperability of computational models in biology.