B Cell Receptor Signaling Drives APOBEC3 Expression Via Direct Enhancer Regulation in Chronic Lymphocytic Leukemia B Cells
Z. Wang, H. Yan, J. C. Boysen, C. R. Secreto, J. Zhong, J. Zhou, H. Gan, C. Yu, E. Braggio, S. L. Slager, S. A. Parikh, N. E. Kay
This study shows BTKi treatment reduces APOBEC3 expression in CLL B cells through enhancer regulation, linking BCR signaling to genomic instability.
bioRxiv · Jul 27, 2021Cancer Biology