J. Zhong

Receptor binding and tissue architecture explain the morphogen local-to-global mobility transition

The paper shows that tissue architecture and receptor binding can explain the transition from local to global morphogen diffusion, without needing additional regulatory mechanisms.

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

Regulation of host metabolism and defense strategies to survive neonatal infection

This study compares metabolic and defense strategies in preterm piglets infected with S. epidermidis, finding that survivors exhibit early resistance and later tolerance, linked to mitochondrial metabolism and improved survival.

Ultraviolet attenuates centromere-mediated meiotic genome stability and alters gametophytic ploidy consistency in flowering plants

This study shows UV radiation reduces crossover rates and disrupts meiotic spindle organization in Arabidopsis, leading to unreduced gametes and altered genome stability.

PP2A catalytic subunit alpha is critically required for CD8+ T cell homeostasis and anti-bacterial responses

This study shows that PP2A catalytic subunit alpha is essential for CD8+ T cell homeostasis and anti-bacterial responses, with Bcl2 rescue limited to spleen.

LRG1 promotes atherosclerosis by activating macrophages

This study identifies LRG1 as a pro-inflammatory factor in atherosclerosis by promoting macrophage M1 polarization through ERK and JNK pathways, and shows that LRG1 inhibition reduces atherosclerosis progression.

Targeting ductal-endothelial crosstalk alleviate pancreatitis

This study shows that blocking integrin-5 signaling reduces acute pancreatitis severity by mitigating ductal-endothelial crosstalk disruption.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Quantitative Learning of Cellular Features From Single-cell Transcriptomics Data Facilitates Effective Drug Repurposing

This study introduces SuperFeat, a framework that uses single-cell transcriptomics data to identify drug targets by modeling adverse cellular states, validated in vitro and in vivo.

Dynamic atP5CS2 Filament Facilitates Substrate Channeling

This study identifies a filament structure in Arabidopsis thaliana P5CS2 that facilitates substrate channeling, enhancing catalytic efficiency in proline synthesis under abiotic stress.

Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma

This study shows nifuroxazide enhances radiotherapy in HCC by reducing PD-L1 expression and improving tumor response.

Timing the Evolution of Phosphorus-Cycling 1 Enzymes Through Geological Time

The paper reconstructs the evolutionary timeline of phosphorus-cycling enzymes and links their development to changes in phosphate concentrations and geological events.

Aminomutation catalyzed by CO2 self-sufficient cascade amino acid decarboxylases

This paper describes an in vitro biotransformation pathway using two decarboxylases to convert -alanine to {beta}-alanine with 100% carbon atom economy by fixing CO2.

Acquired Cross-resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC paralogs

This paper identifies extrachromosomal DNA amplification of MYC paralogs as a recurrent driver of acquired cross-resistance in small cell lung cancer using patient-derived xenograft models.

CytoSIP: An annotated structural atlas for interactions involving cytokine or cytokine receptor

CytoSIP provides a database of cytokine-cytokine receptor interactions with SNPs, interfaces, and disease associations to aid drug design and precision medicine.

Insulin-like Growth Factor-1 Supplementation Promotes Kidney Development and Alleviate Renal Inflammation in Preterm Pigs

This study shows that IGF-1 supplementation improves kidney development and reduces inflammation in preterm pigs.

Use of Artificial Intelligence for Automated Detection and Surveillance of Red Imported Fire Ants Nests

This study develops an AI system using robotic dogs to detect red imported fire ant nests with 95% precision, improving surveillance and pesticide delivery in open fields.

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

Structural basis of bifunctional CTP/dCTP synthase

This study determines the structure of CTP/dCTP synthase bound to deoxynucleotides, revealing its bifunctional mechanism and cellular compartmentation potential.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

GTP cycling gates CTP synthase activation

This study reveals how GTP cycling gates CTP synthase activation through three sequential checkpoints, linking GTP binding and dissociation to catalytic steps in CTP synthesis.

Structural basis of human PRPS2 filaments

This study determines the structure of hPRPS2 polymers using cryo-EM, revealing how ADP binding affects polymerization and catalytic activity.

Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespan

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

Allosteric inhibition of PRPS is moderated by filamentous polymerization

The paper investigates two filament structures of E. coli PRPS resolved by Cryo-EM, revealing how ligand binding modulates allosteric inhibition and PRPP production.

Molecular Crowding Facilitates Bundling of IMPDH Polymers and Cytoophidium Formation

This study shows that molecular crowding promotes IMPDH polymer bundling and cytoophidium formation, with implications for protein stability and subcellular compartment function.

FoQDE2-dependent milRNA promotes Fusarium oxysporum f. sp. cubense virulence by targeting a glycosyl hydrolase coding gene at transcriptional level

Structural basis of dynamic P5CS filaments

This study determines the structure of Drosophila P5CS filament, revealing how filamentation coordinates GK and GPR domains for catalysis.

Characterization of SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.618 on cell entry, host range, and sensitivity to convalescent plasma and ACE2 decoy receptor

This study characterizes SARS-CoV-2 variants Kappa, Delta, and B.1.618, finding increased ACE2 binding in non-human hosts, enhanced spike cleavage, and reduced neutralization sensitivity, but maintained sensitivity to ACE2 decoy receptor.

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.