Arginine valency in C9ORF72 dipolypeptides mediates promiscuous proteome binding that stalls ribosomes, disable actin cytoskeleton assembly and impairs arginine methylation of endogenous proteins
M. Radwan, C.-S. Ang, A. R. Ormsby, D. Cox, J. C. Daly, G. E. Reid, D. M. Hatters
This study shows that arginine valency in C9ORF72 DPRs causes promiscuous proteome binding, ribosome stalling, actin cytoskeleton disruption, and arginine hypomethylation.
bioRxiv · Aug 28, 2019 · PreprintBiochemistry