The N-terminal domain of ALS-linked TDP-43 assembles without misfolding
P. S. Tsoi, K. J. Choi, P. G. Leonard, A. Sizovs, M. M. Moosa, K. R. MacKenzie, J. C. Ferreon, A. C. M. Ferreon
This study shows the N-terminal domain of TDP-43 can oligomerize under physiological conditions, potentially promoting pathological aggregation of the C-terminal domain in neurodegenerative diseases.
bioRxiv · May 4, 2017Biophysics