M. M. Moosa

Heterotypic interactions in the dilute phase can drive co-condensation of prion-like low-complexity domains of FET proteins and mammalian SWI/SNF complex

FUS Oncofusion Protein Condensates Recruit mSWI/SNF Chromatin Remodelers via Heterotypic Interactions Between Prion-like Domains

This study shows FUS-DDIT3 oncofusion protein forms condensates that recruit SWI/SNF chromatin remodelers via PLD-PLD interactions, leading to transcriptional reprogramming.

Programmable Viscoelasticity in Protein-RNA Condensates with Disordered Sticker-Spacer Polypeptides

The paper investigates the viscoelastic properties of protein-RNA condensates formed by sticker-spacer polypeptides and shows how sequence composition tunes their mechanical behavior.

Phase Transition of RNA-protein Complexes into Ordered Hollow Condensates

This study identifies a new phase of RNA-protein condensates forming hollow vesicles through phase separation, distinct from typical liquid droplets.

Interplay Between Short-range Attraction and Long-range Repulsion Controls Reentrant Liquid Condensation of Ribonucleoprotein-RNA Complexes

The paper investigates the molecular forces driving reentrant liquid condensation in RNP-RNA complexes, showing how short-range attractions and long-range repulsions control phase transitions.

Molecular Crowding Tunes Material States of Ribonucleoprotein Condensates

This study investigates how molecular crowding affects the physical properties of RNP condensates, showing they transition from liquid to gel-like states and that this is independent of LCD charge patterns.

The N-terminal domain of ALS-linked TDP-43 assembles without misfolding

This study shows the N-terminal domain of TDP-43 can oligomerize under physiological conditions, potentially promoting pathological aggregation of the C-terminal domain in neurodegenerative diseases.