Author

K. R. MacKenzie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:human· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

A. C. M. Ferreon· 1 shared A. Sizovs· 1 shared B. Sankaran· 1 shared B. VanSchouwen· 1 shared C. W. Kim· 1 shared D. E. Casteel· 1 shared F. W. Herberg· 1 shared G. Kaur· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

A. C. M. Ferreon

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2 papers

Recent·Most cited

An auto-inhibited state of protein kinase G and implications for selective activation

R. Sharma, J. J. Kim, L. Qin, P. Henning, M. Akimoto, B. VanSchouwen, G. Kaur, B. Sankaran, K. R. MacKenzie, G. Melacini, D. E. Casteel, F. W. Herberg, C. W. Kim

This study presents crystal structures of PKG Iβ in auto-inhibited and activated states, revealing the mechanism of cGMP-mediated activation and isoform-specific regulation.

bioRxiv · Apr 28, 2022Biochemistry

The N-terminal domain of ALS-linked TDP-43 assembles without misfolding

P. S. Tsoi, K. J. Choi, P. G. Leonard, A. Sizovs, M. M. Moosa, K. R. MacKenzie, J. C. Ferreon, A. C. M. Ferreon

This study shows the N-terminal domain of TDP-43 can oligomerize under physiological conditions, potentially promoting pathological aggregation of the C-terminal domain in neurodegenerative diseases.

bioRxiv · May 4, 2017Biophysics