Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle
K. B. Kooiker, S. Mohran, K. L. Turner, W. Ma, G. Flint, L. Qi, C. Gao, Y. Zheng, T. S. McMillen, C. Mandrycky, A. Martinson, M. Mahoney-Schaefer, J. C. Freeman, E. G. Costales Arenas, A.-Y. Tu, , F. Moussavi-Harami
This study investigates how Danicamtiv increases force and alters cardiac muscle contraction kinetics by modulating myosin function and cross bridge dynamics in cardiac tissue.
bioRxiv · Jan 31, 2023 · PreprintPhysiology