Accelerating Strain Engineering using Desorption Electrospray Ionization-Imaging Mass Spectrometry and Untargeted Molecular Analysis of Intact Microbial Colonies.
B. M. Ellis, P. Babele, J. C. May, B. F. Pfleger, J. D. Young, J. A. McLean
This paper develops a DESI-IMS assay to rapidly phenotype engineered E. coli strains by analyzing their metabolomes, identifying strategies for strain optimization.
bioRxiv · Apr 1, 2021Bioengineering