Author

J. C. Mock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Assay:protein structure· 1

Frequent Co-Authors

D. Neri· 3 shared M. Stringhini· 2 shared A. M. Villa· 1 shared C. E. Pellegrino· 1 shared I. Astiazaran Rascon· 1 shared M. Catalano· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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3 shared papersCancer Biology

D. Neri

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Engineering murine GITRL for antibody-mediated delivery to tumor-associated blood vessels

J. C. Mock, I. Astiazaran Rascon, M. Stringhini, M. Catalano, D. Neri

This paper develops GITRL-fusion proteins targeting tumor vasculature but finds they fail to show anti-tumor activity in preclinical models.

bioRxiv · Aug 26, 2020 · PreprintCancer Biology

An engineered 4-1BBL fusion protein with ''activity-on-demand''

J. C. Mock, M. Stringhini, A. M. Villa, D. Neri

This paper describes an engineered antibody-cytokine fusion protein that activates only upon antigen binding, showing potent anti-tumor activity with reduced toxicity in mouse models.

bioRxiv · Apr 29, 2020Cancer Biology

A universal reporter cell line for bioactivity evaluation of engineered cytokine products

J. C. Mock, C. E. Pellegrino, D. Neri

The paper develops a universal reporter cell line system for evaluating bioactivity of engineered cytokine products and identifies a mechanism for cytokine potentiation.

bioRxiv · Dec 2, 2019Immunology