Cell BiologybioRxivPreprint
Increased tau expression in the APOE4 blood-brain barrier model is associated with reduced anti-tau therapeutic antibody delivery in vitro.
J. M. Wasielewska, R. Bajracharya, R. L. Johnston…·A. R. White
This study shows that APOE4 increases tau levels in brain endothelial cells, reducing anti-tau antibody delivery across the blood-brain barrier in vitro.
DOI 10.1101/2023.10.24.563706