Author

A. Pebay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. W. Hewitt· 3 shared A. L. Cook· 2 shared K. M. Young· 2 shared S. S. Hung· 2 shared A. Hewitt· 1 shared A. J. Fortune· 1 shared A. R. White· 1 shared A. Senabouth· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

A. W. Hewitt

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Author profile →

5 papers

Recent·Most cited

Increased tau expression in the APOE4 blood-brain barrier model is associated with reduced anti-tau therapeutic antibody delivery in vitro.

J. M. Wasielewska, R. Bajracharya, R. L. Johnston, J. C. S. Chaves, A. Pebay, L. E. Oikari, J. Götz, R. M. Nisbet, A. R. White

This study shows that APOE4 increases tau levels in brain endothelial cells, reducing anti-tau antibody delivery across the blood-brain barrier in vitro.

bioRxiv · Oct 24, 2023 · PreprintCell Biology

Induced pluripotent stem cell derived pericytes respond to endogenous mediators of proliferation and contractility

N. E. King, J.-M. Courtney, L. S. Brown, A. J. Fortune, N. B. Blackburn, J. L. Fletcher, J. M. Cashion, J. Talbot, A. Pebay, A. W. Hewitt, G. P. Morris, K. M. Young, A. L. Cook, B. A. Sutherland

This study compares iPSC-derived pericytes to primary human brain vascular pericytes, showing they express pericyte markers and respond to growth factors and vasoactive mediators, though with gene expression differences.

bioRxiv · Sep 29, 2023Cell Biology

Evolving Transcriptomic Signature of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cells With Age

G. E. Lidgerwood, A. Senabouth, C. J. A. Smith-Anttila, V. Gnanasambandapillai, D. C. Kaczorowski, D. Amann-Zalcenstein, E. L. Fletcher, S. H. Naik, A. W. Hewitt, J. Powell, A. Pebay

This study characterizes the transcriptomic changes in hPSC-derived RPE cells over time in culture, showing a maturing transcriptional profile that resembles native RPE.

bioRxiv · Jul 26, 2020Cell Biology

Comparison of CRISPR/Cas endonucleases for in vivo retinal gene editing.

F. Li, K. Wing, J.-H. Wang, C. D. Luu, J. A. Bender, J. Chen, Q. Wang, Q. Lu, M. T. N. T. Tran, K. M. Young, R. C. Wong, A. Pebay, A. L. Cook, S. S. Hung, G.-S. Liu, A. W. Hewitt

This study compares CRISPR/Cas endonucleases for in vivo retinal gene editing and finds SpCas9 delivered via AAV7m8 achieves the highest knockout efficacy.

bioRxiv · Jun 9, 2020Bioengineering

Mitochondrial replacement in an iPSC model of Leber Hereditary Optic Neuropathy.

R. Wong, S. Y. Lim, S. S. Hung, S. Jackson, S. Khan, N. J. Van Bergen, E. De Smit, H. H. Liang, L. S. Kearns, L. Clarke, D. A. Mackey, A. Hewitt, I. A. Trounce, A. Pebay

The paper uses cybrid technology to replace mtDNA mutations in iPSCs derived from LHON patients, showing reduced RGC death in corrected cells.

bioRxiv · Mar 26, 2017Cell Biology