Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics
J. Serrano-Lopez, S. Hegde, S. Kumar, J. Serrano, J. Fang, A. Wellendorf, P. Roche, Y. Rangel, L. J. Carrington, H. Geiger, L. Grimes, S. Luther, I. Maillard, J. Sanchez-Garcia, D. Starczynowski, J. Cancelas
The paper shows that systemic inflammation triggers rapid migration of specific myeloid progenitors from bone marrow to lymphatics via Ccl19/Ccr7, promoting anti-inflammatory responses and replenishment of lymph node dendritic cells.
bioRxiv · Jan 20, 2021 · PreprintImmunology