Author

J. Clain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:plant (other)· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

R. Coppee· 3 shared A. Sabbagh· 2 shared S. Houze· 2 shared A. Ashish· 1 shared A. Fricot· 1 shared A. Garcia· 1 shared A. Marteau· 1 shared A. Rahman· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBiochemistry

R. Coppee

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation

A. Rahman, S. Tamseel, R. Coppee, S. Dutta, N. Khan, M. Faaiz, H. Rastogi, J. R. Nath, P. Chowdhury, A. Ashish, J. Clain, S. Bhattacharjee

This study shows that PfKelch13 mutants have reduced heme-binding affinity, leading to decreased artemisinin activation and contributing to artemisinin resistance.

bioRxiv · Jan 23, 2024 · PreprintBiochemistry

Genetic profiling of Plasmodium ovale wallikeri relapses with microsatellite markers and whole-genome sequencing

V. Joste, E. Colard-Itte, E. Guillochon, F. Ariey, R. Coppee, J. Clain, S. Houze, French National Reference Center for Imported Malaria Study Group

The paper investigates relapse patterns in Plasmodium ovale wallikeri infections using microsatellite markers and whole-genome sequencing, finding that most relapses are genetically related to primary infections.

bioRxiv · Feb 1, 2023 · PreprintMicrobiology

Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria

B. Henry, G. Volle, H. Akpovi, L. Gineau, C. Roussel, P. A. Ndour, F. Tossou, F. Suarez, F. Palstra, A. Fricot, C. Chambrion, J. Solinc, J. Nguyen, M. Gare, F. Aussenac, , P. Buffet

The paper identifies a genetic mechanism in Fulani individuals that enhances splenic clearance of rigid erythrocytes, contributing to splenomegaly and partial malaria resistance.

bioRxiv · Mar 21, 2022Physiology

Plasmodium falciparum sexual parasites regulate infected erythrocyte permeability

G. Bouyer, D. Barbieri, F. Dupuy, A. Marteau, A. Sissoko, M.-E. N'Dri, G. Neveu, L. Bedault, N. Khodabux, D. Roman, S. Houze, G. Siciliano, P. Alano, R. M. Martins, J.-J. Lopez-Rubio, , C. Lavazec

This study shows that Plasmodium falciparum gametocytes maintain New Permeation Pathways (NPP) regulated by cAMP signaling, which can be reactivated by PDE inhibitors to enhance drug uptake.

bioRxiv · May 18, 2020Microbiology

Structural evolutionary analysis predicts functional sites in the artemisinin resistance malaria protein K13

R. Coppee, D. Jeffares, A. Sabbagh, J. Clain

The paper identifies conserved regions in the K13 protein of Plasmodium falciparum as potential functional sites using evolutionary and structural analysis.

bioRxiv · Jun 21, 2018 · PreprintEvolutionary Biology