From atoms to cells: bridging the gap between potency, efficacy, and safety of small molecules directed at a membrane protein
R. Aguayo-Ortiz, J. Creech, E. N. Jimenez-Vazquez, G. Guerrero-Serna, N. Wang, A. Monteiro da Rocha, T. J. Herron, L. M. Espinoza-Fonseca
This study combines computational and experimental methods to evaluate drug potency, efficacy, and safety for targeting membrane proteins, using SERCA2a as a model.
bioRxiv · Mar 19, 2021Pharmacology & Toxicology