Author

E. N. Jimenez-Vazquez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:electrophysiology· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Jain· 2 shared A. Monteiro da Rocha· 2 shared D. K. Jones· 2 shared G. Guerrero-Serna· 2 shared T. J. Herron· 2 shared A. J. Cuttita· 1 shared A. Macias· 1 shared C. U. Ukachukwu· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPhysiology

A. Jain

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

hERG1 channel subunit composition mediates proton inhibition of IKr in hiPSC CMs

C. U. Ukachukwu, E. N. Jimenez-Vazquez, A. Jain, D. K. Jones

This study shows that changes in hERG1a/1b subunit abundance in hiPSC-CMs affect IKr sensitivity to protons, with mature cells showing reduced inhibition.

bioRxiv · Aug 26, 2022 · PreprintPhysiology

KCNH2 encodes a nuclear-targeted polypeptide that mediates hERG1 channel gating and expression

A. Jain, O. Stack, S. Ghodrati, F. G. Sanchez-Conde, C. Ukachukwu, S. Salwi, E. N. Jimenez-Vazquez, D. K. Jones

This study identifies a nuclear-targeted hERG1 polypeptide, hERG1NP, encoded by KCNH2, which modulates hERG1 channel function during cardiac development.

bioRxiv · Aug 24, 2022 · PreprintCell Biology

SNTA1 GeneRescues Ion Channel Function in Cardiomyocytes Derived from Induced Pluripotent Stem Cells Reprogrammed from Muscular Dystrophy Patients with Arrhythmias

J. Jalife, E. N. Jimenez-Vazquez, M. Arad, A. Macias, M. L. Vera-Pedrosa, F. M. Cruz, A. J. Cuttita, A. Monteiro da Rocha, T. J. Herron, D. Ponce-Balbuena, G. Guerrero-Serna, O. Binah, D. E. Michele

This study shows that iPSC-CMs from DMD patients with arrhythmias have NaV1.5-Kir2.1 channelosome dysfunction, which can be rescued by 1-syntrophin.

bioRxiv · Jan 25, 2022 · PreprintCell Biology

From atoms to cells: bridging the gap between potency, efficacy, and safety of small molecules directed at a membrane protein

R. Aguayo-Ortiz, J. Creech, E. N. Jimenez-Vazquez, G. Guerrero-Serna, N. Wang, A. Monteiro da Rocha, T. J. Herron, L. M. Espinoza-Fonseca

This study combines computational and experimental methods to evaluate drug potency, efficacy, and safety for targeting membrane proteins, using SERCA2a as a model.

bioRxiv · Mar 19, 2021Pharmacology & Toxicology