Author

G. Guerrero-Serna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Monteiro da Rocha· 2 shared E. N. Jimenez-Vazquez· 2 shared L. M. Espinoza-Fonseca· 2 shared T. J. Herron· 2 shared A. J. Cuttita· 1 shared A. Macias· 1 shared C. Cruz-Cortes· 1 shared D. E. Michele· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersCell Biology

A. Monteiro da Rocha

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Activation mechanism of the cardiac calcium pump by a small-molecule allosteric modulator

J. Seflova, C. Cruz-Cortes, G. Guerrero-Serna, S. L. Robia, L. M. Espinoza-Fonseca

This study uses TCSPC imaging to show that CDN1163, a SERCA2a activator, synergizes with ATP to shift SERCA2a toward a competent conformation, enhancing its function under physiological conditions.

bioRxiv · Sep 7, 2023 · PreprintBiophysics

SNTA1 GeneRescues Ion Channel Function in Cardiomyocytes Derived from Induced Pluripotent Stem Cells Reprogrammed from Muscular Dystrophy Patients with Arrhythmias

J. Jalife, E. N. Jimenez-Vazquez, M. Arad, A. Macias, M. L. Vera-Pedrosa, F. M. Cruz, A. J. Cuttita, A. Monteiro da Rocha, T. J. Herron, D. Ponce-Balbuena, G. Guerrero-Serna, O. Binah, D. E. Michele

This study shows that iPSC-CMs from DMD patients with arrhythmias have NaV1.5-Kir2.1 channelosome dysfunction, which can be rescued by 1-syntrophin.

bioRxiv · Jan 25, 2022 · PreprintCell Biology

From atoms to cells: bridging the gap between potency, efficacy, and safety of small molecules directed at a membrane protein

R. Aguayo-Ortiz, J. Creech, E. N. Jimenez-Vazquez, G. Guerrero-Serna, N. Wang, A. Monteiro da Rocha, T. J. Herron, L. M. Espinoza-Fonseca

This study combines computational and experimental methods to evaluate drug potency, efficacy, and safety for targeting membrane proteins, using SERCA2a as a model.

bioRxiv · Mar 19, 2021Pharmacology & Toxicology