Combined transient ablation and single cell RNA sequencing reveals the development of medullary thymic epithelial cells
K. L. Wells, C. N. Miller, A. R. Gschwind, W. Wei, J. D. Phipps, M. S. Anderson, L. M. Steinmetz
The paper uses transient ablation and single-cell RNA sequencing to study mTEC development, revealing a transit-amplifying population preceding Aire expression and a branching model of differentiation.
bioRxiv · Jun 19, 2020Immunology