M. S. Anderson

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk

The paper shows how non-coding variants affecting IL2RA enhancers alter T cell feedback circuits, leading to opposing autoimmune outcomes in mice.

Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities

This paper validates a murine proteome-wide PhIP-seq library to identify autoantibody specificities in autoimmune disease models.

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq

This paper scales PhIP-Seq for autoantibody discovery across multiple autoimmune diseases and COVID19, enabling machine learning predictions and identification of disease-specific autoantigens.

Therapeutic Interruption of T Cell Development Generates High-Affinity T Cells That Escape Exhaustion and Improve Cancer Immunotherapy

This study shows that interrupting central tolerance generates high-affinity T cells that avoid exhaustion and enhance cancer immunotherapy.

Microbiota-instructed regulatory T cell differentiation is mediated by a distinct RORγt+ antigen presenting cell subset

This study identifies a distinct RORγt+ antigen presenting cell subset that mediates microbiota-driven regulatory T cell differentiation, revealing a mechanism for maintaining immune tolerance.

Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Populations with Unique Homology to Thymic Epithelium

This paper identifies two extrathymic Aire-expressing cell types with transcriptional and genomic similarities to thymic epithelium and shows their role in immune tolerance.

T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk

This study identifies two enhancers regulating IL2RA expression in T cells, showing how their cell-type-specific effects influence autoimmune diabetes risk.

Combined transient ablation and single cell RNA sequencing reveals the development of medullary thymic epithelial cells

The paper uses transient ablation and single-cell RNA sequencing to study mTEC development, revealing a transit-amplifying population preceding Aire expression and a branching model of differentiation.

Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by PhIP-Seq

This study uses PhIP-Seq to identify novel autoantigens in APS1, linking specific autoantibodies to clinical phenotypes like ovarian insufficiency and intestinal dysfunction.

Exploration of Anti-Yo and Anti-Hu paraneoplastic neurological disorders by PhIP-Seq reveals a highly restricted pattern of antibody epitopes

This study uses PhIP-Seq to identify epitopes of anti-Yo and anti-Hu autoantibodies in PND patients, revealing restricted antigenic patterns and potential biomarkers.