Author

L. M. Steinmetz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Organism:yeast· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. R. Gschwind· 2 shared C. Jann· 2 shared A. H. Smits· 1 shared A. Johansson· 1 shared A.-M. Michon· 1 shared C. Bibi· 1 shared C. Herrmann· 1 shared C. Kee· 1 shared

Activity by Year

2018-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersImmunology

A. R. Gschwind

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut

S. Triana, C. Metz Zumaran, C. Ramirez, C. Kee, P. Doldan, M. Shahraz, D. Schraivogel, A. R. Gschwind, L. M. Steinmetz, C. Herrmann, T. Alexandrov, S. Boulant, M. L. Stanifer

This study identifies enterocytes as the main target of SARS-CoV-2 in the gut and shows the virus suppresses interferon signaling to evade immune response.

bioRxiv · Oct 21, 2020Immunology

CRISPRi screens reveal genes modulating yeast growth in lignocellulose hydrolysate

F. Gutmann, C. Jann, F. Pereira, A. Johansson, L. M. Steinmetz, K. R. Patil

The paper uses CRISPRi screens in yeast to identify genes affecting growth in lignocellulose hydrolysate, revealing known and new targets for improving industrial fermentation.

bioRxiv · Sep 17, 2020Microbiology

The mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

S. Backes, Y. S. Bykov, M. Raeschle, J. Zhou, S. Lenhard, L. Kraemer, T. Muehlhaus, C. Bibi, C. Jann, J. D. Smith, L. M. Steinmetz, D. Rapaport, Z. Storchova, M. Schuldiner, F. Boos, J. M. Herrmann

The paper identifies Tom70's role in recruiting cytosolic chaperones to the mitochondrial outer membrane to mitigate proteotoxicity from hydrophobic precursor proteins.

bioRxiv · Sep 14, 2020Cell Biology

Combined transient ablation and single cell RNA sequencing reveals the development of medullary thymic epithelial cells

K. L. Wells, C. N. Miller, A. R. Gschwind, W. Wei, J. D. Phipps, M. S. Anderson, L. M. Steinmetz

The paper uses transient ablation and single-cell RNA sequencing to study mTEC development, revealing a transit-amplifying population preceding Aire expression and a branching model of differentiation.

bioRxiv · Jun 19, 2020Immunology

Biological Plasticity Rescues Target Activity in CRISPR Knockouts

A. H. Smits, F. Ziebell, G. Joberty, N. Zinn, W. F. Mueller, S. Clauder-Münster, D. Eberhard, M. Fälth Savitski, P. Grandi, P. Jakob, A.-M. Michon, H. Sun, K. Tessmer, T. Bürckstümmer, M. Bantscheff, , W. Huber

The paper quantifies residual protein expression in CRISPR-Cas9 knockouts using RNA-seq and SPS-MS3, identifying mechanisms of partial protein preservation and functional retention.

bioRxiv · Jul 26, 2019Bioengineering

NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells

J. Becker-Kettern, N. Paczia, J.-F. Conrotte, C. Zhu, O. Fiehn, P. P. Jung, L. M. Steinmetz, C. L. Linster

This study shows that NAD(P)HX repair deficiency in yeast and human cells causes metabolic perturbations, including NADHX accumulation, NAD+ depletion, and impaired mitochondrial function.

bioRxiv · Jul 5, 2018Biochemistry