Increased abundance of Cbl E3 ligases alters PDGFR signaling in recessive dystrophic epidermolysis bullosa
E. M. Martinez, R. Toelle, J. Donauer, C. Gretzmeier, L. Bruckner-Tuderman, J. Dengjel
The paper shows that in RDEB, increased Cbl E3 ligase activity due to TGFβ signaling impairs PDGFR signaling, leading to reduced wound healing.
bioRxiv · May 10, 2021Biochemistry