J. Dengjel

Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy

This study uses targeted proteomics to analyze protein degradation patterns during autophagy, revealing differential responses of selective autophagy receptors to various stimuli.

The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization

This study identifies BAG2 as an effector of the ULK1 complex that modulates AMBRA1 localization to regulate autophagy initiation under different nutritional conditions.

Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation

This study shows Snf1/AMPK inhibits TORC1 during glucose starvation via Pib2 and Sch9 phosphorylation, integrating glucose and glutamine signals to regulate cell growth.

The lectin LecB induces patches with basolateral characteristics at the apical membrane to promote Pseudomonas aeruginosa host cell invasion

This paper identifies LecB as a Pseudomonas aeruginosa lectin that triggers PI3K signaling and caveolin-1 recruitment at the apical membrane to promote host cell invasion.

The pyruvate dehydrogenase complex regulates mitophagic selectivity and matrix protein phosphorylation

The paper identifies a novel role of the pyruvate dehydrogenase complex in regulating mitophagic selectivity independently of its enzymatic activity.

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

The paper shows TBK1 phosphorylates TNIP1, activating its LIR-dependent autophagy-mediated degradation, which promotes pro-inflammatory gene expression.

Fibrin, Bone Marrow Cells and macrophages interactively modulate cardiomyoblast fate.

This study shows that fibrin and bone marrow cells reduce cardiac damage and improve function after myocardial infarction by modulating macrophage behavior and promoting cardiomyoblast proliferation.

Increased abundance of Cbl E3 ligases alters PDGFR signaling in recessive dystrophic epidermolysis bullosa

The paper shows that in RDEB, increased Cbl E3 ligase activity due to TGFβ signaling impairs PDGFR signaling, leading to reduced wound healing.

The Pseudomonas aeruginosa lectin LecB causes integrin internalization to facilitate crawling of bacteria underneath host cells

This paper shows that Pseudomonas aeruginosa's LecB lectin binds integrins and causes their internalization, enabling bacterial crawling under host cells.

Phosphorylation of mitochondrial matrix proteins regulates their selective mitophagic degradation

This study identifies phosphorylation of mitochondrial matrix proteins as a mechanism regulating selective mitophagic degradation in yeast, involving phosphatase Aup1 and kinases Pkp1/Pkp2.