BiochemistrybioRxiv
Exposing the molecular heterogeneity of glycosylated biotherapeutics
L. F. Schachner, C. Mullen, W. Phung…·W. Sandoval
This paper introduces a new method for analyzing glycoform heterogeneity in biotherapeutics using mass spectrometry and bioinformatics, showing its effectiveness in measuring proteoform diversity and correlating glycoform sub-populations with pharmacological properties.
DOI 10.1038/s41467-024-47693-8