Author

L. F. Schachner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:proteomics· 2 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

K. Jooss· 2 shared M. A. Cheek· 2 shared M. J. Meiners· 2 shared M.-C. Keogh· 2 shared N. L. Kelleher· 2 shared S. A. Howard· 2 shared A. ElSohly· 1 shared A. Lee· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

K. Jooss

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3 papers

Recent·Most cited

Exposing the molecular heterogeneity of glycosylated biotherapeutics

L. F. Schachner, C. Mullen, W. Phung, J. D. Hinkle, M. I. Beardsley, T. Bentley, P. Day, C. Tsai, S. Sukumaran, T. Baginski, D. DiCara, N. Agard, M. Masureel, J. Gober, A. ElSohly, , W. Sandoval

This paper introduces a new method for analyzing glycoform heterogeneity in biotherapeutics using mass spectrometry and bioinformatics, showing its effectiveness in measuring proteoform diversity and correlating glycoform sub-populations with pharmacological properties.

bioRxiv · May 10, 2023Biochemistry

Separation and Characterization of Endogenous Nucleosomes by Native Capillary Zone Electrophoresis - Top-Down Mass Spectrometry (nCZE-TDMS)

K. Jooss, L. F. Schachner, R. Watson, Z. B. Gillespie, S. A. Howard, M. A. Cheek, M. J. Meiners, J. D. Licht, M.-C. Keogh, N. L. Kelleher

The paper introduces nCZE-TDMS, a platform for separating and characterizing nucleosomes, histone subunits, and PTMs, and applies it to study histone modifications in cell lines with altered NSD2/MMSET expression.

bioRxiv · Nov 25, 2020Biochemistry

Decoding the Protein Composition of Whole Nucleosomes with Nuc-MS

L. F. Schachner, K. Jooss, M. A. Morgan, A. Piunti, M. J. Meiners, A. Lee, J. O. Kafader, M. Iwanaszko, M. A. Cheek, J. M. Burg, S. A. Howard, M.-C. Keogh, A. Shilatifard, N. L. Kelleher

The paper introduces Nuc-MS, a method to analyze protein composition of whole nucleosomes, revealing specific histone variants and modifications associated with oncogenic states.

bioRxiv · Sep 8, 2020Biochemistry