Lipid interactions enhance activation and potentiation of cystic fibrosis transmembrane conductance regulator (CFTR)
S. Chin, M. Ramjeesingh, M. Hung, J. Ereno-Oreba, C. E. Ing, Z. W. Zeng, H. Cui, J.-P. Julien, R. Pomes, C. Bear
This study shows that lipid interactions are crucial for CFTR channel activation and potentiation, as demonstrated by higher catalytic activity and response to ivacaftor when CFTR is purified with associated lipids.
bioRxiv · Dec 16, 2018 · PreprintBiophysics