J.-P. Julien

A general platform for targeting MHC-II antigens via a single loop

This paper introduces TRACeR-II, a platform for developing MHC-II binders using a single loop, demonstrating its versatility and applicability to SARS-CoV-2 peptides.

Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats

The paper identifies human antibodies targeting Plasmodium falciparum sexual stages, revealing cross-stage recognition of glutamate-rich repeats through a novel method.

Molecular and functional properties of human Plasmodium falciparum CSP C-terminus antibodies

This study characterizes human antibodies targeting the PfCSP C-terminal domain, finding limited protective activity and suggesting exclusion from malaria vaccine design.

Antibody avidity and multi-specificity combined to confer protection against SARS-CoV-2 and resilience against viral escape

This study develops a multimeric antibody platform (Multabody) that enhances neutralization potency and breadth against SARS-CoV-2 and its variants through avidity and multi-specificity.

Dual inhibition of vacuolar ATPase and TMPRSS2 is required for complete blockade of SARS-CoV-2 entry into cells

This study identifies bafilomycin A1 as a potent inhibitor of SARS-CoV-2 entry via the endosomal route and shows synergy with TMPRSS2 inhibitors.

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

Polymeric assembly of endogenous Tuberous Sclerosis Protein Complex

The paper demonstrates that endogenous Tuberous Sclerosis Protein Complex (pTSC) assembles into filamentous super-structures in mammalian brains.

A Versatile Soluble Siglec Scaffold for Sensitive and Quantitative Detection of Glycan Ligands

This paper introduces a versatile Siglec-Fc scaffold for detecting glycan ligands, revealing new patterns on healthy and cancerous cells and clarifying ligand specificities, including for CD33.

Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1

This study identifies tryptophan residues in SOD1 and TDP-43 that mediate cross-seeding and toxicity in ALS, suggesting a druggable target for therapeutic intervention.

Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11

This study investigates how antibody 3D11 binds to Plasmodium berghei CSP repeats, inducing structural ordering and revealing common mechanisms of antibody evolution against Plasmodium CSP.

De novo protein design enables precise induction of functional antibodies in vivo

This paper introduces a de novo protein design algorithm called TopoBuilder that generates immunogens inducing precise antibody responses against respiratory syncytial virus in mice and non-human primates.

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

This study characterizes a monoclonal antibody against the N-terminal domain of PfCSP, finding it has high affinity but lacks functional inhibitory activity against sporozoites.

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

The paper characterizes 200 human monoclonal PfCSP antibodies, showing that high affinity to a conserved NANP motif, not cross-reactivity, correlates with parasite inhibition and protection.

Lipid interactions enhance activation and potentiation of cystic fibrosis transmembrane conductance regulator (CFTR)

This study shows that lipid interactions are crucial for CFTR channel activation and potentiation, as demonstrated by higher catalytic activity and response to ivacaftor when CFTR is purified with associated lipids.