Diploid hepatocytes drive physiological liver renewal in adult humans
P. Heinke, F. Rost, J. Rode, T. Welsch, K. Alkass, J. Feddema, M. Salehpour, G. Possnert, H. Druid, L. Brusch, O. Bergmann
The paper uses 14C birth dating to show human hepatocytes continuously renew, with diploid cells having a seven-fold higher turnover rate than polyploid cells.
bioRxiv · Aug 7, 2020 · PreprintCell Biology