Author

L. Brusch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2 Bioengineering· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:human· 5 Approach:statistical model· 4 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

F. Rost· 4 shared J. Rode· 3 shared F. Segovia-Miranda· 2 shared H. Druid· 2 shared H. Morales-Navarrete· 2 shared K. Alkass· 2 shared M. Salehpour· 2 shared M. Zerial· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

F. Rost

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A latent cardiomyocyte regeneration potential in the human heart

W. Derks, J. Rode, S. Collin, F. Rost, P. Heinke, A. Hariharan, L. Pickel, I. Simonova, E. Lazar, E. Graham, R. Jashari, M. Andrae, A. Jeppsson, M. Salehpour, K. Alkass, , O. Bergmann

This study shows that cardiomyocyte renewal is significantly reduced in end-stage heart failure but increases in patients with improved cardiac function from left ventricle support devices.

bioRxiv · Sep 14, 2023Cell Biology

Diploid hepatocytes drive physiological liver renewal in adult humans

P. Heinke, F. Rost, J. Rode, T. Welsch, K. Alkass, J. Feddema, M. Salehpour, G. Possnert, H. Druid, L. Brusch, O. Bergmann

The paper uses 14C birth dating to show human hepatocytes continuously renew, with diploid cells having a seven-fold higher turnover rate than polyploid cells.

bioRxiv · Aug 7, 2020 · PreprintCell Biology

A Modular Framework for Multiscale Spatial Modeling of Viral Infection and Immune Response in Epithelial Tissue

T. J. Sego, J. O. Aponte-Serrano, J. Ferrari Gianlupi, S. Heaps, K. Breithaupt, L. Brusch, J. Crawshaw, J. M. Osborne, E. M. Quardokus, R. K. Plemper, J. A. Glazier

The paper introduces a modular simulation platform to model viral infection and immune response in epithelial tissue, showing that early low-dose antiviral treatment is more effective than late high-dose treatment.

bioRxiv · Apr 27, 2020Bioengineering

3D spatially-resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression

F. Segovia-Miranda, H. Morales-Navarrete, M. Kucken, V. Moser, S. Seifert, U. Repnik, F. Rost, A. Hendriks, S. Hinz, C. Rocken, D. Luthjohann, Y. Kalaidzidis, C. Schafmayer, L. Brusch, J. Hampe, M. Zerial

This study creates 3D spatial models of human liver tissue to identify new morphometric parameters and topological defects linked to NAFLD progression.

bioRxiv · Mar 9, 2019Pathology

How fast are cells dividing: Probabilistic model of continuous labeling assays

J. Rode, T. Goerke, L. Brusch, F. Rost

The paper develops a probabilistic model to accurately estimate cell proliferation rates from continuous labeling assays, accounting for biological variability and showing current methods can be biased.

bioRxiv · Feb 25, 2019 · PreprintBiophysics

Liquid-crystal organization of liver tissue

H. Morales-Navarrete, H. Nonaka, A. Scholich, F. Segovia-Miranda, W. de Back, K. Meyer, R. L. Bogorad, V. Koteliansky, L. Brusch, Y. Kalaidzidis, F. Julicher, B. M. Friedrich, M. Zerial

The paper reveals that hepatocytes in liver tissue follow a long-range liquid-crystal order, challenging the traditional view of random organization and highlighting bi-directional communication between hepatocytes and sinusoids.

bioRxiv · Dec 13, 2018Biophysics