Sustained mechanical tension governs fibrogenic activation of tendon stromal cells in systemic sclerosis
A. A. Hussien, R. Knell, F. Renoux, S. Wunderli, B. Niederoest, J. Foolen, O. Distler, J. G. Snedeker
This study shows that sustained mechanical tension drives fibrogenic activation of tendon stromal cells in systemic sclerosis, revealing a feedback loop between fibroblasts and ECM stiffening.
bioRxiv · Jun 11, 2021Cell Biology