J. G. Moffat

Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2

This study identifies 14 ATP-competitive ERK2 inhibitors that select for the R-state conformation, revealing structural changes and allosteric communication mechanisms.

Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2

This paper shows how different ERK2 inhibitors shift conformational states by exploiting activation loop dynamics, affecting dephosphorylation rates.