Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2
L. M. Pegram, J. C. Liddle, Y. Xiao, M. Hoh, J. Rudolph, D. B. Iverson, G. P. Vigers, D. Smith, H. Zhang, W. Wang, J. G. Moffat, N. G. Ahn
This paper shows how different ERK2 inhibitors shift conformational states by exploiting activation loop dynamics, affecting dephosphorylation rates.
bioRxiv · May 16, 2019Biochemistry