The STAT5-IRF4-BATF pathway drives heightened epigenetic remodeling in naïve CD4+ T cell responses of older adults
H. Zhang, R. R. Jadhav, W. Cao, I. N. Goronzy, J. Jin, W. J. Greenleaf, C. M. Weyand, J. Goronzy
The paper examines age-related changes in T cell responses by analyzing transcriptional and epigenetic profiles of naive CD4+ T cells from young and older adults, identifying increased epigenetic remodeling and effector cell differentiation.
bioRxiv · Aug 27, 2021 · PreprintImmunology