Author

J. H. Borowsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:simulation· 1 Approach:statistical model· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

G. R. Bowman· 2 shared M. D. Ward· 2 shared M. I. Zimmerman· 2 shared N. Vithani· 2 shared S. Singh· 2 shared A. M. Harbison· 1 shared A. Meller· 1 shared B. Novak· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

G. R. Bowman

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential

N. Vithani, M. D. Ward, M. I. Zimmerman, B. Novak, J. H. Borowsky, S. Singh, G. R. Bowman

This paper investigates how Nsp10 activates Nsp16 and identifies a cryptic pocket in SARS-CoV-2 Nsp16 that could be targeted for pan-coronavirus antivirals.

bioRxiv · Dec 10, 2020Biophysics

SARS-CoV-2 Simulations Go Exascale to Capture Spike Opening and Reveal Cryptic Pockets Across the Proteome

M. I. Zimmerman, J. R. Porter, M. D. Ward, S. Singh, N. Vithani, A. Meller, U. L. Mallimadugula, C. E. Kuhn, J. H. Borowsky, R. P. Wiewiora, M. F. D. Hurley, A. M. Harbison, C. A. Fogarty, J. E. Coffland, E. Fadda, , G. R. Bowman

The paper uses exascale simulations to study SARS-CoV-2 protein dynamics, revealing cryptic epitopes and conformational changes that inform antiviral target design.

bioRxiv · Jun 27, 2020 · PreprintBiophysics