IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence
S. Pereira Ribeiro, M. Aid, F. P. Dupuy, C. Ngai Chan, J. Hultquist, C. Deleage, E. Moysi, D. A. Kulpa, L. Li, X. Xu, B. Tamilselvan, J. A. Tomalka, M. Nekorchuk, K. Busman-Sahay, R. Bordi, , R.-P. Sekaly
The paper shows IL-10 promotes HIV persistence by supporting memory T cell survival and Tfh differentiation, and inhibiting IL-10 reduces HIV reservoirs.
bioRxiv · Feb 26, 2021 · PreprintImmunology