Acyl-CoA thioesterase-2 facilitates beta-oxidation in glycolytic skeletal muscle in a lipid supply dependent manner
C. Bekeova, J. I. Han, H. Xu, E. Kerr, B. Blackburne, S. C. Lynch, C. Mesaros, M. Murgia, R. Vadigepalli, J. Beld, R. Leonardi, N. W. Snyder, E. L. Seifert
This study shows ACOT2 regulates acyl-CoA levels in glycolytic muscle, promoting β-oxidation when lipid supply is low but causing lipid accumulation and poor glucose homeostasis when lipid supply is high.
bioRxiv · Jun 27, 2023 · PreprintBiochemistry