Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5
J. I. Roop, N. A. Cassidy, A. S. Dingens, J. D. Bloom, J. Overbaugh
This study identifies HIV-1 Env mutations that enhance entry into macaque cells using deep mutational scanning, finding mutations that increase entry up to 38-fold and affect antibody sensitivity.
bioRxiv · Dec 3, 2019Microbiology