J. J. Gardner

Oxidative stress induces release of mitochondrial DNA into the extracellular space in human placental villous trophoblast BeWo cells

This study shows oxidative stress induces mtDNA release and non-apoptotic cell death in BeWo trophoblast cells, with implications for placental pathology and ccf-mtDNA biomarkers.

Pregnancy-associated oxidative stress and inflammation are not associated with impaired maternal neuronal activity or memory function

This study examines the effects of pregnancy-related oxidative stress and inflammation on maternal hippocampal function and cognitive performance in rats, finding elevated oxidative stress markers in pregnant rats but no impact on memory or anxiety-like behavior.

Gestational exposure to unmethylated CpG oligonucleotides dysregulates placental molecular clock network and fetoplacental growth dynamics, and disrupts maternal blood pressure circadian rhythms in rats

MultIscale MultiObjective Systems Analysis (MIMOSA): an advanced metabolic modeling framework for complex systems

The paper introduces MIMOSA, a metabolic modeling framework that tracks individual cells in space and time, improving predictive modeling of complex cell cultures.