Cancer BiologybioRxiv
BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
D. Edwards, R. Maganti, J. P. Tanksley…·S. R. Floyd
This study shows BET bromodomain inhibitors cause DNA damage by inducing R-loops and transcription-replication conflicts through impaired transcription elongation.
DOI 10.1016/j.celrep.2020.108166