Author

J. J. Salk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

L. A. Loeb· 2 shared A. Vanderstichele· 1 shared B. Kohrn· 1 shared C. C. Valentine· 1 shared D. Nachmanson· 1 shared E. H. Ahn· 1 shared E. Loter· 1 shared E. Maritschnegg· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

L. A. Loeb

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2 papers

Recent·Most cited

Unexpectedly High Subclonal Mutational Diversity in Human Colorectal Cancer and Its Significance

L. A. Loeb, B. Kohrn, K. J. Loubet-Senear, Y. J. Dunn, E. H. Ahn, J. N. O'Sullivan, J. J. Salk, M. P. Bronner, R. A. Beckman

This study quantifies subclonal mutations in colorectal cancer using Duplex Sequencing, revealing high mutation rates and confirming neutral evolution in tumors.

bioRxiv · Jun 21, 2019Cancer Biology

Ultra-sensitive sequencing for cancer detection reveals progressive clonal selection in normal tissue over a century of human lifespan

J. J. Salk, K. Loubet-Senear, E. Maritschnegg, C. C. Valentine, L. N. Williams, R. Horvat, A. Vanderstichele, D. Nachmanson, K. T. Baker, M. J. Emond, E. Loter, T. Soussi, L. A. Loeb, R. Zeillinger, P. Speiser, R. A. Risques

This study uses ultra-sensitive sequencing to detect TP53 mutations in normal tissues across age, showing that age-related mutations share clonal selection traits with tumor mutations.

bioRxiv · Nov 4, 2018Cancer Biology