PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Y. P. Kang, A. Falzone, M. Liu, J. J. Saller, F. A. Karreth, G. M. DeNicola
This study shows PHGDH depletion in adult mice is tolerated, with normal liver and pancreatic function, but reduced PHGDH leads to altered lipid homeostasis in the liver.
bioRxiv · Nov 12, 2019Biochemistry