F. A. Karreth

MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability

This study identifies PHGDH induction via MAPK and mTORC1 pathways as essential for melanoma formation and shows that combining BRAFV600E inhibition with serine restriction can target this vulnerability.

The lipid phosphatase activity of PTEN dampens FRA1 expression via AKT/mTOR signaling to suppress melanoma

This study shows PTEN's lipid phosphatase activity suppresses melanoma by inhibiting AKT/mTOR signaling and reducing FRA1 expression.

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

This study investigates the role of Nrf2 signaling thresholds in lung tumor initiation and progression using murine models with KEAP1 and NRF2 mutations.

Chromosome 1q amplification perturbs a ceRNA network to promote melanoma metastasis

The paper shows that chromosome 1q amplification promotes melanoma metastasis by overexpressing ceRNAs that sequester tumor suppressor miRNAs.

MAPK-induced miR-29 targets MAFG and suppresses melanoma development

This study shows that MAPK-induced miR-29 suppresses melanoma by targeting MAFG, and its inactivation accelerates tumor development.

PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

This study shows PHGDH depletion in adult mice is tolerated, with normal liver and pancreatic function, but reduced PHGDH leads to altered lipid homeostasis in the liver.

A versatile ES cell-based melanoma mouse modeling platform

This paper develops an ESC-based melanoma mouse model platform to rapidly generate genetically engineered mice for melanoma research using multiple genetic strategies.

Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem

This paper proposes mathematical models to adapt radiotherapy plans based on tumor-immune ecosystem composition and immune responses to improve outcomes in non-small cell lung cancer.