Age-related susceptibility to insulin resistance is due to a combination of CPT1B decline and lipid overload
M. A. Vieira-Lara, M. B. Dommerholt, W. Zhang, M. Blankestijn, J. C. Wolters, F. Abegaz, Y. van der Veen, T. H. van Dijk, R. van Os, D.-J. Reijngoud, J. W. Jonker, J. K. Kruit, B. M. Bakker
This study shows that age-related insulin resistance in mice is caused by both reduced CPT1B and lipid overload, not just mitochondrial dysfunction or diet alone.
bioRxiv · Feb 4, 2021Biochemistry