Humanized mice bearing CRISPR/Cas9 Disruption of Signal Transducer and Activator of Transcription 1 (STAT1) to Model Primary Immunodeficiency
J. L. Aron, T. J. Thauland, H. A. Khan, M. J. Butte
This study uses CRISPR/Cas9 to disrupt STAT1 in human hematopoietic stem cells, creating humanized mice that model partial STAT1 deficiency and replicate human immune system impairments.
bioRxiv · Jun 20, 2022 · PreprintImmunology