M. J. Butte

Humanized mice bearing CRISPR/Cas9 Disruption of Signal Transducer and Activator of Transcription 1 (STAT1) to Model Primary Immunodeficiency

This study uses CRISPR/Cas9 to disrupt STAT1 in human hematopoietic stem cells, creating humanized mice that model partial STAT1 deficiency and replicate human immune system impairments.

Global anti-tumor immunity after localized, bioengineered Treg depletion

This paper presents a biodegradable scaffold that locally depletes Tregs and activates T cells to clear solid tumors, inducing an immunological abscopal effect on distant tumors.

Expanding the Potential Genes of Inborn Errors of Immunity through Protein Interactions

The paper identifies 2,530 genes potentially related to inborn errors of immunity by linking known genes to new ones through protein interactions and analyzing their genetic variation and expression in immune cells.

IL-10 Promotes Endothelial Progenitor Cell Driven Wound Neovascularization and Enhances Healing via STAT3.

This study shows IL-10 promotes wound healing by recruiting endothelial progenitor cells through STAT3-dependent regulation of VEGF and SDF-1 in both control and diabetic wounds.

T-cell activation is modulated by the 3D mechanical microenvironment

This study shows that T-cell activation increases in stiffer 3D hydrogels compared to softer ones, indicating mechanical sensing by T cells.

The actin-capping protein alpha-adducin is required for T-cell costimulation

This study shows that alpha-adducin is required for CD4+ T-cell activation in response to low antigen levels but not for CD8+ T-cell activation or infection response, and it abrogates CD28 costimulatory signals.