The Synergy between Topography and Lipid Domains in the Plasma Membrane of Mast Cells Controls the Localization of Signaling Proteins and Facilitates their Coordinated Activation
Shirsendu Ghosh, Alice Wagenknecht-Wiesner, Shriya Desai, Jada Vyphuis, Mariena Silvestry Ramos, J. L. Grazul, Barbara A. Baird
This paper shows that ordered lipid nanodomains and microvilli in mast cells coordinate to localize signaling proteins, enabling efficient antigen-triggered immune responses.
Proceedings of the National Academy of Sciences · Jul 17, 2025Peer-reviewedImmunology